PF 4693627 - PF 04693627

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2020

CAS [1312815-93-2]

MF C26H29Cl2N3O3
MW 502.43

Purity: 100%
Optical purity: d.e. >98%
Soluble in DMSO

PF 4693627

Description

Potent, selective and orally bioavailable inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) for the potential treatment of inflammation (IC50 value 3 nM and 109 nM in enzyme assay and WHB assay respectively). PF 4693627 shows excellent in vitro and in vivo properties and is selective against relevant human enzymes COX-2, TXAS, PGDS, 5-LOX, 15-LOX and 12-LOX.

G.B. Arhancet et al. Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorg. Med. Chem. Lett. 2013, 23, 1114-1119.

D.P. Walker et al. Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design. Bioorg. Med. Chem. Lett. 2013, 23, 1120-1126.

Selective and orally bioavailable inhibitor of mPGES-1

Chemical name

1-(5-chloro-6-(4-chlorophenyl)benzo[d]oxazol-2-yl)-N-((1S,3S)-3-(hydroxymethyl)cyclohexyl)piperidine-4-carboxamide

Parent CAS No.

[1312815-93-2]

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Size	Unit Price	Stock
5 mg	€130.00	In Stock
25 mg	€470.00	In Stock

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PF 4693627 - PF 04693627

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PF 4693627 - PF 04693627

Description

Chemical name

Parent CAS No.

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