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Apremilast
- CC 10004
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C22H24N2O7S
- MW: 460.5
Description
More Information
| Parent CAS No. | 608141-41-9 |
|---|---|
| Chemical Name | (S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide |
| SMILES | C(NC1=CC=CC2=C1C(=O)N([C@@H](C1=CC=C(OC)C(OCC)=C1)CS(C)(=O)=O)C2=O)(=O)C |&1:11,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1 |
| InChiKey | IMOZEMNVLZVGJZ-QGZVFWFLSA-N |
| CID | 11561674 |
| Short Description | PDE4 inhibitor |
References
- K Papp et al. Efficacy of apremilast in the treatment of moderate to severe psoriasis: a randomised controlled trial. Lancet, 2012, 380 (9843), 738-746.
- P Schafer. Apremilast mechanism of action and application to psoriasis and psoriatic arthritis. Biochem. Pharmacol. 2012, 83 (12), 1583–1590.
- FE McCann et al. Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Arthritis Res. Ther. 2010, 12(3), R107.
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