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A 803467
- Soluble in DMSO
- MF: C19H16ClNO4
- MW: 357.79
Description
A 803467 is a potent and selective Nav1.8 voltage-gated sodium channel blocker with a reported IC50 value of 8 nM.
Nav1.8 is preferentially expressed in peripheral sensory neurons and contributes to nociceptor excitability and pain transmission. A 803467 is a valuable tool for studying Nav1.8-dependent firing and analgesic mechanisms.
Key Features
- Selective Nav1.8 sodium channel blocker
- IC50: 8 nM
- Targets nociceptor sodium-channel excitability
- Useful for pain-pathway pharmacology
Applications
- Nav1.8 channel pharmacology
- Nociceptor excitability and pain model studies
- Electrophysiology and sodium-current assays
- Peripheral sensory neuron research
More Information
| Parent CAS No. | 944261-79-4 |
|---|---|
| Chemical Name | 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide |
| SMILES | O1C(C2=CC=C(Cl)C=C2)=CC=C1C(NC1=CC(OC)=CC(OC)=C1)=O |
| MFCD | MFCD10574689 |
| InChi | InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22) |
| InChiKey | VHKBTPQDHDSBSP-UHFFFAOYSA-N |
| CID | 16038374 |
| Short Description | Nav1.8 blocker |
References
- MF Jarvis et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc. Natl. Acad. Sci. 2007, 104(20), 8520-8525.
- S McGaraughty et al. A Selective Nav1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats. J. Pharmacol. Exp. Ther. 2008, 324(3), 1204-1211.
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