Bulk Inquiry
GW 788388
- Soluble in DMSO
- MF: C25H23N5O2
- MW: 425.48
Description
Potent, orally active and selective inhibitor of transforming growth factor β receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5).
More Information
| Parent CAS No. | 452342-67-5 |
|---|---|
| Chemical Name | 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide |
| SMILES | C1(C2N=CC=CC=2)=NNC=C1C1C=C(C2C=CC(C(=O)NC3CCOCC3)=CC=2)N=CC=1 |
| MFCD | MFCD16038936 |
| InChi | InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31) |
| InChiKey | SAGZIBJAQGBRQA-UHFFFAOYSA-N |
| CID | 10202642 |
| Short Description | ALK5 inhibitor |
References
- SM Tan et al. Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 2010, 298, H1415-1425.
- F Gellibert et al. Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor (...). J. Med. Chem. 2006, 49(7), 2210-2221.
- M Petersen et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int. 2008, 73(6), 705-15.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1387 | SD 208 |
From $55.00 |
| 1421 | A 83-01 |
From $77.00 |
| 1491 | LY 2157299 |
From $66.00 |
| 1509 | LDN 193189 hydrochloride |
From $71.50 |
| 1661 | SB 431542 |
From $77.00 |
| 1708 | Dorsomorphin |
From $71.50 |
| 1744 | A 77-01 |
From $88.00 |
| 2150 | Dorsomorphin dihydrochloride |
From $71.50 |
| 2189 | K 02288 |
From $99.00 |
| 2197 | SB 505124 |
From $104.50 |
| 2201 | LDN 212854 trihydrochloride |
From $121.00 |
| 2236 | IN 1130 |
From $104.50 |
| 2285 | SB 525334 |
From $115.50 |
| 2323 | ITD 1 |
From $115.50 |
| 2467 | (+)-ITD-1 |
From $181.50 |
| 2764 | SIS3 |
From $148.50 |
| 2943 | SRI-011381 hydrochloride |
From $137.50 |
| 3076 | TJ191 |
From $132.00 |
| 3404 | LY-364947 |
From $99.00 |
| 3892 | LY-3200882 |
From Inquiry |
| 3971 | CCT196969 |
From Inquiry |
| 4168 | BMS-986260 |
From $132.00 |
| 4385 | RepSox |
From $132.00 |
