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T 1776Na
Axon 1769
- Parent CAS: 1202076-01-4
Purity:
99%
- Limited soluble in DMSO
- MF: C25H18NNaO4
- MW: 419.4
Description
T 1776Na is an inhibitor of plasminogen activator inhibitor-1 (PAI-1/SERPINE1).
PAI-1 controls fibrinolysis by inhibiting tissue-type and urokinase-type plasminogen activators and is implicated in thrombosis, fibrosis and metabolic disease. T 1776Na is useful for studying PAI-1-dependent protease regulation.
Key Features
- Inhibits PAI-1/SERPINE1 activity
- Modulates fibrinolytic pathway regulation
- Relevant to thrombosis and fibrosis biology
- Useful small-molecule tool for serpin pathway studies
Applications
- PAI-1 functional assays
- Fibrinolysis and thrombosis research
- Fibrosis pathway studies
- Protease inhibitor pharmacology
More Information
| Parent CAS No. | 1202076-01-4 |
|---|---|
| Chemical Name | sodium (Z)-2-(3-((5-oxo-3,4-diphenyl-1H-pyrrol-2(5H)-ylidene)methyl)phenyloxo-3,4-diphenyl-1H-pyrrol-2(5H)-ylidene)methyl)phenoxy)acetate |
| SMILES | C1(C2C=CC=CC=2)/C(=C/C2C=CC=C(OCC(=O)[O-])C=2)/NC(=O)C=1C1C=CC=CC=1.[Na+] |
| MFCD | N.A. |
| InChi | InChI=1S/C25H19NO4.Na/c27-22(28)16-30-20-13-7-8-17(14-20)15-21-23(18-9-3-1-4-10-18)24(25(29)26-21)19-11-5-2-6-12-19;/h1-15H,16H2,(H,26,29)(H,27,28);/q;+1/p-1/b21-15-; |
| InChiKey | DSDPFXYQTHXQHS-XGRJIHFXSA-M |
| CID | 44235156 |
| Short Description | PAI-1 inhibitor |
References
- H Miyazaki et al. Synthesis and Evaluation of Pyrrolin-2-one Compounds, a Series of Plasminogen Activator Inhibitor-1 Inhibitors. Chem. Pharm. Bull. 2009, 57(9), 979-985.
- H Miyazaki et al. Evaluation of pyrrolin-2-one derivatives synthesized by a new practical method as inhibitors of plasminogen activator inhibitor-1 (PAI-1). Bioorg. Med. Chem. Lett. 2010, 20(2), 546-548.
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