INCB 024360 - Epacadostat

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1733

CAS [1204669-58-8]

MF C11H13BrFN7O4S
MW 438.23

  • Purity: 98%
  • Soluble in DMSO

INCB 024360

Description

Potent competitive inhibitor of indoleamine 2,3-dioxygenase (IDO1, IC50 value 72 nM in vitro) with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model; INCB024360 (Epacadostat) decreased kynurenine levels by >50% in plasma and inhibited B16-GM-CSF tumor growth in a dose dependent fashion.

An analog of INCB 024360 (Axon 2215) is available as well.

KEYWORDS: INCB 24360 |  IDO1 inhibitor | Axon 1733 | Epacadostat | INCB 024360 | INCB024360 | INCB24360 | CAS [1204669-58-8] | [1204669-37-3] | Kynurenine | cancer | immunotherapy | melanoma | hydroxamidine

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Size Unit Price Stock
5 mg €105.00 In Stock
25 mg €365.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €160.00 In Stock
2 x 25 mg €560.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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