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RO 61-8048
Axon 2139
CAS:
199666-03-0
Purity:
99%
- Soluble in DMSO
- MF: C17H15N3O6S2
- MW: 421.45
Description
Potent, selective and reversible inhibitor of kynurenine-3-monooxygenase (KMO, or kynurenine hydroxylase) activity (IC50: 37 nM); cell-permeable and competitive
More Information
| Parent CAS No. | 199666-03-0 |
|---|---|
| Chemical Name | 3,4-dimethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)benzenesulfonamide |
| SMILES | C1C=C(S(NC2=NC(C3C=C([N+]([O-])=O)C=CC=3)=CS2)(=O)=O)C=C(OC)C=1OC |
| MFCD | MFCD11040807 |
| InChi | InChI=1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19) |
| InChiKey | NDPBMCKQJOZAQX-UHFFFAOYSA-N |
| CID | 5282337 |
| Short Description | KMO inhibitor |
References
- R. Cozzi et al. Kynurenine hydroxylase inhibitors reduce ischaemic brain damage: studies with (m-nitrobenzoyl)alanine and 3,4-dimethoxy-[N-4-(nitrophenyl)thiazol-2-yl]-benzenesulfonamide (...). J. Cereb. Blood Flow Metab., 1999, 19, 771–777.
- A. Chiarugi, F. Moroni. Quinolinic acid formation in immuno-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[N-4-(3-nitrophenyl)thiazol-2-yl[benzenesulphonamide (Ro61-8048), (...). Neuropharmacol. 1999, 38, 1225–1233.
- TW Stone. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends in Pharmacol. Sci. 2000, 21(4), 149–154.
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