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FK 866 hydrochloride
- K 22.175 hydrochloride
Axon 1546
- Parent CAS: 658084-64-1
Purity:
99%
- Soluble in water and DMSO
- MF: C24H29N3O2.HCl
- MW: 427.97
Description
FK 866 hydrochloride (K22.175) is a highly specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), a rate-limiting enzyme in the NAD salvage pathway. FK866 hydrochloride is the preferred water-soluble salt of FK866 (Axon 1279)
NAMPT inhibition depletes intracellular NAD, disrupting metabolic homeostasis and sensitizing tumor cells to energetic stress. FK 866 is widely used to study NAD biosynthesis, cancer metabolism and metabolic dependencies in proliferating cells.
Key Features
- Selective NAMPT inhibitor
- Blocks the NAD salvage biosynthesis pathway
- Induces metabolic stress and tumor cell apoptosis
- Reference compound for NAD-depletion studies
Applications
- NAD metabolism and salvage pathway research
- Cancer metabolism assays
- Metabolic vulnerability screening
- NAMPT inhibitor pharmacology
More Information
| Parent CAS No. | 658084-64-1 |
|---|---|
| Chemical Name | (E)-N-[4-(1-Benzoyl-piperidin-4-yl)-butyl]-3-pyridin-3-yl-acrylamide hydrochloride |
| SMILES | C1CC(CCCCNC(=O)/C=C/C2C=NC=CC=2)CCN1C(=O)C1C=CC=CC=1.Cl |
| MFCD | MFCD10565943 |
| InChi | InChI=1S/C24H29N3O2.ClH/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22;/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28);1H/b12-11+; |
| InChiKey | MULSIBUGDPOSHV-CALJPSDSSA-N |
| CID | 78243733 |
| Short Description | NAMPT inhibitor |
FK 866 hydrochloride (K22.175)
selective NAMPT inhibitor
FK 866 hydrochloride
K22.175
K 22.175 hydrochloride
FK866
NAMPT
Inhibitor
NAD metabolism and salvage pathway research
Cancer metabolism assays
Metabolic vulnerability screening
NAMPT inhibitor pharmacology
apoptosis
cancer biology
metabolism
drug discovery
receptor selectivity
enzyme pharmacology
CAS 2727965-45-7
CAS 658084-64-1
Axon Medchem
Axon 1546
Supplier
Vendor
References
- M. Hasmann and I. Schemainda, FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res. 2003, 63, 7436-7442.
- A Pogrebniak et al. Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents. Eur. J. Med. Res. 2006, 11(8), 313-321.
- K Holen et al. The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Invest. New Drugs. 2008, 26(1), 45-51.
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