AZ 628

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1545

CAS [878739-06-1]

MF C27H25N5O2
MW 451.52

Purity: 99%
Soluble in DMSO

AZ 628

Description

Selective RAF inhibitor, showing strong selectivity for RAF kinases among a panel of 150 tested kinases; IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF

C Montagut et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008, 68(12), 4853–4861.

G Hatzivassiliou et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010, 464, 431-435.

B-Raf and C-Raf protein kinase inhibitor

Chemical name

3-(Cyano-dimethyl-methyl)-N-[4-methyl-3-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-phenyl]-benzamide

Parent CAS No.

[878739-06-1]

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5 mg	€80.00	In Stock
25 mg	€240.00	In Stock

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2 x 25 mg	€360.00	In Stock

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AZ 628

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AZ 628

Description

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