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Parogrelil
- NT 702, free base - NM 702
- Soluble in DMSO
- MF: C19H18BrClN4O2
- MW: 449.73
Description
Parogrelil (NT702) is a potent and selective phosphodiesterase 3 (PDE3) inhibitor that increases intracellular cyclic AMP by limiting its enzymatic degradation. This mechanism supports both smooth-muscle relaxation and modulation of inflammatory cell responses.
Parogrelil has been investigated as a dual bronchodilatory and anti-inflammatory agent. It is particularly useful for studying how PDE3-dependent cAMP signaling regulates airway tone, inflammatory mediator release and pulmonary pharmacology.
Key Features
- Potent and selective PDE3 inhibitor
- Elevates intracellular cAMP by inhibiting cyclic nucleotide hydrolysis
- Combines bronchodilatory and anti-inflammatory pharmacology
- Useful for linking PDE3 activity to airway smooth-muscle and immune responses
Applications
- PDE3 and cyclic AMP signaling studies
- Airway smooth-muscle relaxation assays
- Pulmonary inflammation research
- Bronchodilator pharmacology and respiratory disease models
More Information
| Parent CAS No. | 139145-27-0 |
|---|---|
| Chemical Name | 4-bromo-6-[3-(4-chlorophenyl)propoxy]-5-[(pyridin-3-ylmethyl)amino]-2,3-dihydropyridazin-3-one |
| SMILES | C1(CNC2=C(Br)C(=O)NN=C2OCCCC2C=CC(Cl)=CC=2)C=CC=NC=1 |
| MFCD | MFCD13195583 |
| InChi | InChI=1S/C19H18BrClN4O2/c20-16-17(23-12-14-3-1-9-22-11-14)19(25-24-18(16)26)27-10-2-4-13-5-7-15(21)8-6-13/h1,3,5-9,11H,2,4,10,12H2,(H2,23,24,26) |
| InChiKey | YJMYSLFFZJUXOA-UHFFFAOYSA-N |
| CID | 9803788 |
| Short Description | PDE3 inhibitor |
References
- M Hori et al. NT-702 (parogrelil hydrochloride, NM-702), a novel and potent phosphodiesterase 3 inhibitor, suppress the asthmatic response in guinea pigs, with both bronchodilating and anti-inflammatory effects. Eur. J. Pharmacol. 2009, 618(1-3), 63-69.
- N Ishiwata. NT-702, a novel and potent phosphodiesterase inhibitor, improves reduced walking distance and lowered hindlimb plantar surface temperature in a rat experimental intermittent claudication model. Life Sci. 2007, 81(12), 970-978.
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