Eplivanserin - SR 46349B

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1439

CAS [130580-02-8]

MF C19H21FN2O2.½C4H4O4
MW 386.42

Purity: 99%
Soluble in DMSO

Eplivanserin

Description

Potent, selective and p.o. active 5-HT2A antagonist; functionally also an inverse agonist of 5-HT2A receptor; no affinity to dopamine, histamine and adrenergic receptors; therapeutic agent for the treatment of insomnia

M. Rinaldi-Carmona et al. Biochemical and Pharmacological Properties of SR 46349B, a New Potent and Selective 5-Hydroxytryptamine2 Receptor Antagonist. JPET 1992, 262(2), 759-768.

F Chaouloff et al. Repeated DOI and SR 46349B treatments do not affect elevated plus-maze anxiety despite opposite effects on cortical 5-HT2A receptors. Eur. J. Pharmacol. 1997, 334(1), 25-29.

BR Teergarden et al. 5-HT2A Inverse-Agonists for the Treatment of Insomnia. Current Topics Med. Chem. 2008, 8(11), 969–976.

CNS 5-HT2A A17

5-HT2A antagonist/inverse agonist

Chemical name

(E)-1-(2-Fluoro-phenyl)-3-(4-hydroxy-phenyl)-propenone O-(2-dimethylamino-ethyl)-oxime hemi-fumarate

Parent CAS No.

[130579-75-8]

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5 mg	€80.00	In Stock
10 mg	€110.00	In Stock
50 mg	€380.00	In Stock

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