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SNC 80
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq)
- MF: C28H39N3O2
- MW: 449.63
Description
SNC 80 is a potent and selective delta-opioid receptor (DOR) agonist that activates Gi/o-coupled OPRD1 signaling.
SNC 80 is a nonpeptide agonist used to study δ-opioid regulation of analgesia, mood, reward and seizure susceptibility. Its receptor selectivity makes it a valuable comparator against μ- and κ-opioid pharmacology.
Key Features
- Selective δ-opioid receptor agonist
- Nonpeptide ligand with CNS activity
- Activates Gi/o-coupled OPRD1 signaling
- Useful for opioid receptor subtype comparisons
Applications
- δ-Opioid receptor functional assays
- Analgesia and nociception research
- Mood and reward-pathway studies
- Opioid receptor selectivity profiling
More Information
| Parent CAS No. | 156727-74-1 |
|---|---|
| Chemical Name | 4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-N,N-diethyl-benzamide |
| SMILES | C1(C(N(CC)CC)=O)C=CC([C@]([H])(C2C=CC=C(OC)C=2)N2[C@@H](C)CN(CC=C)[C@H](C)C2)=CC=1 |&1:11,22,29,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1 |
| InChiKey | KQWVAUSXZDRQPZ-UMTXDNHDSA-N |
| CID | 123924 |
| Short Description | δ-opioid agonist |
References
- SN Calderon et al. Probes for narcotic receptor mediated phenomena. 19. Synthesis of SNC 80: a highly selective, nonpeptide delta opioid receptor agonist. J. Med. Chem. 1994, 37, 2125.
- Bilsky et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. J. Pharmacol. Exp. Ther. 1995, 273, 359.
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