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BAY 19-8004
- Lirimilast
- Soluble in DMSO
- MF: C17H12Cl2N2O6S
- MW: 443.26
Description
Selective inhibitor of phosphodiesterase-4 (PDE4).
More Information
| Parent CAS No. | 329306-27-6 |
|---|---|
| Chemical Name | Methanesulfonic acid 2-(2,4-dichloro-benzoyl)-3-ureido-benzofuran-6-yl ester |
| SMILES | C1C=C2C(NC(N)=O)=C(C(=O)C3C(Cl)=CC(Cl)=CC=3)OC2=CC=1OS(C)(=O)=O |
| MFCD | MFCD09837901 |
| InChi | InChI=1S/C17H12Cl2N2O6S/c1-28(24,25)27-9-3-5-11-13(7-9)26-16(14(11)21-17(20)23)15(22)10-4-2-8(18)6-12(10)19/h2-7H,1H3,(H3,20,21,23) |
| InChiKey | YPFLFUJKZDAXRA-UHFFFAOYSA-N |
| CID | 6433118 |
| Short Description | PDE4 inhibitor |
References
- D.C. Grootendorst et al. Efficacy of the novel phosphodiesterase-4 inhibitor BAY 19-8004 on lung function and airway inflammation in asthma and chronic obstructive pulmonary disease (COPD). Pulmonary Pharmacol. Ther. 16 (2003) 341–347.
- P. Norman. PDE4 inhibitors: sustained patenting activity as leading drugs near the market. Exp. Opin. Ther. Pat.2000, 10, 9, 1415-1427.
- D.C. Grootendorst, K.F. Rabe. Selective phosphodiesterase inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. Curr. Opin. Allergy Clin. Immunol. 2002, 2(1), 61-67.
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