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KY 05009

Axon 2395
CAS:  1228280-29-2
Purity:  99%
  • Soluble in DMSO
  • MF:  C18H16N4O2S
  • MW:  352.41

Description

Inhibitor of Traf2- and Nck-Interacting Kinase (TNIK; Ki value 100 nM in ATP-competitive assay) that attenuates TGF-β1-mediated Wnt and Smad signaling and epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma A549 cells. Additionally, KY05009 inhibits TGF-β1-induced phosphorylation of JNK1/2, FAK, Src, and paxillin.

More Information

Parent CAS No. 1228280-29-2
Chemical Name 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide
SMILES S1C(NC(=O)C2=CC=C(C)C=C2)=C(C(N)=O)N=C1NC1=CC=CC=C1
MFCD N.A.
InChi InChI=1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24)
InChiKey WCEDGRTWDSHZHF-UHFFFAOYSA-N
CID 46234348
Short Description TNIK inhibitor

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