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SRT 1720 tetrahydrochloride
- Parent CAS: 925434-55-5
- Soluble in water and DMSO
- MF: C25H23N7OS.4HCl
- MW: 615.41
Description
More Information
| Parent CAS No. | 925434-55-5 |
|---|---|
| Chemical Name | N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide tetrahydrochloride |
| SMILES | C12N=C(C(NC3=CC=CC=C3C3N=C4N(C=3)C(CN3CCNCC3)=CS4)=O)C=NC1=CC=CC=2.Cl.Cl.Cl.Cl |
| MFCD | MFCD14584468 |
| InChi | InChI=1S/C25H23N7OS.4ClH/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31;;;;/h1-8,13,15-16,26H,9-12,14H2,(H,29,33);4*1H |
| InChiKey | GHXREYLRFHWLCV-UHFFFAOYSA-N |
| CID | 91826485 |
| Short Description | SIRT1 activator |
References
- JC Milne et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007, 450(7170), 712–7160.
- H Dai et al. SIRT1 activation by small molecules - kinetic and biophysical evidence for direct interaction of enzyme and activator. J. Biol. Chem. 2010, 285(43), 32695–32703.
- E Callaway. GlaxoSmithKline strikes back over anti-ageing pills: Drugs do work as thought, says pharmaceutical giant. Nature 2010-08-16.
- RK Minor et al. SRT1720 improves survival and healthspan of obese mice. Scientific Reports 2011, 1, 70.
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