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SRPIN 340
- Soluble in DMSO
- MF: C18H18F3N3O
- MW: 349.35
Description
More Information
| Parent CAS No. | 218156-96-8 |
|---|---|
| Chemical Name | N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide |
| SMILES | C1=NC=CC(C(NC2=CC(C(F)(F)F)=CC=C2N2CCCCC2)=O)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25) |
| InChiKey | DWFGGOFPIISJIT-UHFFFAOYSA-N |
| CID | 2797577 |
| Short Description | SRPK inhibitor |
References
- Y. Karakama et al. Inhibition of Hepatitis C Virus Replication by a Specific Inhibitor of Serine-Arginine-Rich Protein Kinase. Antimicrob. Agents Chemother. 2010, 54, 3179-3186.
- T. Fukuhara et al. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. PNAS USA. 2006, 103, 11329-11333.
- S. Oltean et al. SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases. Biochem. Soc. Trans. 2012, 40, 831–835.
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