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Cambinol
- NSC 112546
- Soluble in DMSO
- MF: C21H16N2O2S
- MW: 360.43
Description
Cambinol inhibits NAD-dependent deacetylase activity of human SIRT1 and SIRT2 (IC50 values of 56 and 59 μM, respectively). Consistent with the role of SIRT1 in promoting cell survival during stress, inhibition of SIRT1 activity with cambinol during genotoxic stress leads to hyperacetylation of key stress response proteins and promotes cell cycle arrest. Cambinol exerts antitumor activity in vitro and in mouse xenograft studies. Moreover, cambinol is an uncompetitive nSMase2 inhibitor (Ki value of 7 μM).
More Information
| Parent CAS No. | 14513-15-6 |
|---|---|
| Chemical Name | 5-((2-Hydroxynaphthalen-1-yl)methyl)-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one |
| SMILES | C1C=C2C(CC3=C(C4C=CC=CC=4)NC(=S)NC3=O)=C(O)C=CC2=CC=1 |
| MFCD | MFCD09057543 |
| InChi | InChI=1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7-2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26) |
| InChiKey | RVNSQVIUFZVNAU-UHFFFAOYSA-N |
| CID | 3246390 |
| Short Description | SIRT inhibitor |
References
- B Heltweg et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 Apr 15;66(8):4368-77.
- M Figuera-Losada et al. Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. PLoS One. 2015 May 26;10(5):e0124481.
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