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MKC-3946
Axon 3670
CAS:
1093119-54-0
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C21H20N2O3S
- MW: 380.46
Description
MKC-3946 is a potent and selective IRE1α inhibitor with an IC50 value of 0.39 μM.
More Information
| Parent CAS No. | 1093119-54-0 |
|---|---|
| Chemical Name | 2-Hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde |
| SMILES | C1(O)=C(C=O)C2C=CC(C3SC(C(=O)N4CCN(C)CC4)=CC=3)=CC=2C=C1 |
| MFCD | MFCD30496700 |
| InChi | InChI=1S/C21H20N2O3S/c1-22-8-10-23(11-9-22)21(26)20-7-6-19(27-20)15-2-4-16-14(12-15)3-5-18(25)17(16)13-24/h2-7,12-13,25H,8-11H2,1H3 |
| InChiKey | IVQVBMWPWPTSNO-UHFFFAOYSA-N |
| CID | 59599728 |
| Short Description | IRE1α inhibitor |
References
- M Mimura et al. Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma. Blood. 2012 Jun 14;119(24):5772-81.
- M Sanches et al. Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun. 2014 Aug 28;5:4202.
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