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MKC8866
Axon 3223
CAS:
1338934-59-0
Purity:
99%
- Soluble in DMSO
- MF: C18H19NO7
- MW: 361.35
Description
MKC8866 is a potent IRE1α RNase-specific inhibitor with an IC50 value of 0.29 μM. In MM1 myeloma cells, MKC8866 strongly inhibited DTT-induced XBP1s expression with an EC50 of 0.52 μM.
More Information
| Parent CAS No. | 1338934-59-0 |
|---|---|
| Chemical Name | 7-Hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde |
| SMILES | C12OC(=O)C(CC(N3CCOCC3)=O)=C(C)C1=CC(OC)=C(O)C=2C=O |
| MFCD | MFCD31540824 |
| InChi | InChI=1S/C18H19NO7/c1-10-11-7-14(24-2)16(22)13(9-20)17(11)26-18(23)12(10)8-15(21)19-3-5-25-6-4-19/h7,9,22H,3-6,8H2,1-2H3 |
| InChiKey | IFDGMRMUJYGWQQ-UHFFFAOYSA-N |
| CID | 89542346 |
| Short Description | IRE1α inhibitor |
References
- T Wilhelm et al. Infliction of proteotoxic stresses by impairment of the unfolded protein response or proteasomal inhibition as a therapeutic strategy for mast cell leukemia. Oncotarget. 2017 Dec 17;9(3):2984-3000.
- X Sheng et al. IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nat Commun. 2019 Jan 24;10(1):323.
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