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Kartogenin
- KGN
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C20H15NO3
- MW: 317.34
Description
Small molecule promoting robust chondrocyte differentiation from primary human mesenchymal stem cells (MSCs; EC50 value 100 nM). Kartogenin (KGN) treatment of bone marrow stromal cells (BMSCs) induced the expresion of both Col. II and aggrecan in a dose-dependent manner, and upregulates Sox-9 gene expression. KGN does not alter either MMP-3, MMP-13, or aggrecanase expression in primary chondrocytes and MSCs.
KGN may be used to enhance tendon/bone interface healing through the direct, local delivery of KGN injections into the gap between the tendon graft and the bone surface during ACL reconstruction.
More Information
| Parent CAS No. | 4727-31-5 |
|---|---|
| Chemical Name | 2-(biphenyl-4-ylcarbamoyl)benzoic acid |
| SMILES | C(O)(=O)C1=CC=CC=C1C(NC1=CC=C(C2=CC=CC=C2)C=C1)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24) |
| InChiKey | SLUINPGXGFUMLL-UHFFFAOYSA-N |
| CID | 2826191 |
| Short Description | Chondrogenesis promotor |
References
- K. Johnson et al. A stem cell-based approach to cartilage repair. Science. 2012, 336, 717-721.
- J. Zhang et al. Kartogenin induces cartilage-like tissue formation in tendon-bone junction. Bone Res. 2014, 2, pii: 14008.
- M.L. Kang et al. Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration. Biomaterials. 2014, 35, 9984-9994.
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