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Olmesartan
- RNH-6270
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C24H26N6O3
- MW: 446.5
Description
Olmesartan is a potent and selective nonpeptide antagonist at the angiotensin II AT1-receptor subtype with an IC50 value of 6.7 nM.
More Information
| Parent CAS No. | 144689-24-7 |
|---|---|
| Chemical Name | 1-((2'-(1H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid |
| SMILES | C1(CN2C(CCC)=NC(C(O)(C)C)=C2C(=O)O)C=CC(C2C=CC=CC=2C2NN=NN=2)=CC=1 |
| MFCD | MFCD09749896 |
| InChi | InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29) |
| InChiKey | VTRAEEWXHOVJFV-UHFFFAOYSA-N |
| CID | 158781 |
| Short Description | AT1 antagonist |
References
- M Mizuno et al. Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist. Eur J Pharmacol. 1995 Oct 16;285(2):181-8.
- M Ojima et al. In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J Pharmacol Exp Ther. 2011 Mar;336(3):801-8.
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