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BHPI
- MF: C21H17NO3
- MW: 331.36
Description
BHPI is a potent noncompetitive ERα inhibitor that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells (IC50 values of 27 and 15 nM in MDA-468 and T47D cell lines, respectively). Moreover, BHPI induced rapid and substantial tumor regression in a mouse xenograft model of breast cancer.
More Information
| Parent CAS No. | 56632-39-4 |
|---|---|
| Chemical Name | 3,3-Bis(4-hydroxyphenyl)-7-methylindolin-2-one |
| SMILES | C1C=C2C(C3C=CC(O)=CC=3)(C3C=CC(O)=CC=3)C(=O)NC2=C(C)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H17NO3/c1-13-3-2-4-18-19(13)22-20(25)21(18,14-5-9-16(23)10-6-14)15-7-11-17(24)12-8-15/h2-12,23-24H,1H3,(H,22,25) |
| InChiKey | FABLAHMQSQFDHR-UHFFFAOYSA-N |
| CID | 3860640 |
| Short Description | ER-α antagonist |
References
- MK Uddin et al. Syntheses and antiproliferative evaluation of oxyphenisatin derivatives. Bioorg Med Chem Lett. 2007 May 15;17(10):2854-7.
- ND Andruska et al. Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4737-42.
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