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PPT
- Soluble in DMSO
- MF: C24H22N2O3
- MW: 386.44
Description
Specific estrogen receptor α (ERα) agonist. PPT significantly decreased infarct size in an in vivo rabbit model of ischemia-reperfusion injury.
More Information
| Parent CAS No. | 263717-53-9 |
|---|---|
| Chemical Name | 1,3,5-Tri-(4'-hydroxyphenyl)-4-propyl-1H-pyrazole |
| SMILES | N1(C2C=CC(O)=CC=2)C(C2C=CC(O)=CC=2)=C(CCC)C(C2C=CC(O)=CC=2)=N1 |
| MFCD | MFCD03453628 |
| InChi | InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3 |
| InChiKey | IOTXSIGGFRQYKW-UHFFFAOYSA-N |
| CID | 5040063 |
| Short Description | ER-α agonist |
References
- Harris et al. Characterization of the biological roles of the estrogen receptors, ERα and ERβ, in estrogen target tissues in vivo through the use of an ERα-selective ligand. Endocrinology 2002, 143, 4172.
- EA Booth et al. Activation of estrogen receptor-alpha protects the in vivo rabbit heart from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H2039-47.
- WR Harrington et al. Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol Cell Endocrinol. 2003 Aug 29;206(1-2):13-22.
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