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TAE226
- NVP-TAE226
- Soluble in DMSO
- MF: C23H25ClN6O3
- MW: 468.94
Description
TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and a moderately potent IGF-1R inhibitor (IC50 of 140 nM). TAE 226 was also found to be effective as inhibitor for Pyk2 (with a reported IC50 of 3.5 nM) and insulin receptor (InsR) (with a reported IC50 of 44 nM). Furthermore TAE226 was also found to induce apoptosis.
More Information
| Parent CAS No. | 761437-28-9 |
|---|---|
| Chemical Name | 2-(5-Chloro-2-(2-methoxy-4-morpholinophenylamino)pyrimidin-4-ylamino)-N-methylbenzamide |
| SMILES | C1C=CC(NC2C(Cl)=CN=C(NC3C=CC(N4CCOCC4)=CC=3OC)N=2)=C(C(NC)=O)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H25ClN6O3/c1-25-22(31)16-5-3-4-6-18(16)27-21-17(24)14-26-23(29-21)28-19-8-7-15(13-20(19)32-2)30-9-11-33-12-10-30/h3-8,13-14H,9-12H2,1-2H3,(H,25,31)(H2,26,27,28,29) |
| InChiKey | UYJNQQDJUOUFQJ-UHFFFAOYSA-N |
| CID | 9934347 |
| Short Description | FAK and IGF-1R inhibitor |
References
- TJ Liu et al. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther. 2007 Apr;6(4):1357-67.
- EA Beierle et al. TAE226 inhibits human neuroblastoma cell survival. Cancer Invest. 2008 Mar;26(2):145-51.
- A Schultze et al. TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis. Invest New Drugs. 2010 Dec;28(6):825-33.
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