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LDN 212854
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C25H22N6
- MW: 406.48
Description
Potent ALK2-biased BMP type I receptor kinase inhibitor (IC50 values 2.4 nM, 1.3 nM, and 85.8 nM for ALK1, 2, and 3 resp.), showing nearly 4 orders of selectivity for BMP versus the closely related TGF-β and Activin type I receptors. Closely related to LDN 193189 (Axon 1509). Note: Trihydrochloride salt form of LDN 212854 (Axon 2201) is also available.
More Information
| Parent CAS No. | 1432597-26-6 |
|---|---|
| Chemical Name | 5-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline |
| SMILES | C1(C2C=CC(N3CCNCC3)=CC=2)=CN2N=CC(C3C4C=CC=NC=4C=CC=3)=C2N=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C25H22N6/c1-3-21(22-4-2-10-27-24(22)5-1)23-16-29-31-17-19(15-28-25(23)31)18-6-8-20(9-7-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 |
| InChiKey | BBDGBGOVJPEFBT-UHFFFAOYSA-N |
| CID | 60182388 |
| Short Description | BMP inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
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