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Vadadustat
- AKB6548 - PG-1016548
Axon 3288
CAS:
1000025-07-9
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C14H11ClN2O4
- MW: 306.7
Description
Vadadustat (AKB6548 - PG-1016548) is a titratable, oral HIF prolyl-4-hydroxylase (HIF-PH or PHD) inhibitor and HIF stabilizer.
More Information
| Parent CAS No. | 1000025-07-9 |
|---|---|
| Chemical Name | 2-(5-(3-Chlorophenyl)-3-hydroxypicolinamido)acetic acid |
| SMILES | C1(C(NCC(=O)O)=O)C(O)=CC(C2C=C(Cl)C=CC=2)=CN=1 |
| MFCD | MFCD30470233 |
| InChi | InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20) |
| InChiKey | JGRXMPYUTJLTKT-UHFFFAOYSA-N |
| CID | 23634441 |
| Short Description | HIF-PH inhibitor |
References
- PE Pergola et al. Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis- dependent chronic kidney disease. Kidney Int 2016 Nov;90(5):1115-1122.
- AA Joharapurkar et al. Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases. J Med Chem 2018 Aug 23;61(16):6964-6982.
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