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AR7
- Atypical retinoid 7
- Soluble in DMSO
- MF: C15H12ClNO
- MW: 257.71
Description
Atypical RARα receptor antagonist that stimulates CMA (chaperone-mediated autophagy) activity without detectable changes in other autophagic pathways, making cells more resistant to oxidative stress and proteotoxicity. AR7 is also known as a hypoxia targeted compound for cancer therapeutics (IC50 value 10 μM for inhibition of hypoxic cancer cell growth (MTT assay) in HepG2 cells while sparing ‘normoxic’ cells).
More Information
| Parent CAS No. | 80306-38-3 |
|---|---|
| Chemical Name | 7-chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine |
| SMILES | O1C2=CC(Cl)=CC=C2N=C(C2=CC=C(C)C=C2)C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H12ClNO/c1-10-2-4-11(5-3-10)14-9-18-15-8-12(16)6-7-13(15)17-14/h2-8H,9H2,1H3 |
| InChiKey | MVOZLTFXYGHZPM-UHFFFAOYSA-N |
| CID | 44250175 |
| Short Description | RARα antagonist |
References
- BC Das et al. Design, synthesis and biological evaluation of 2H-benzo[b][1,4] oxazine derivatives as hypoxia targeted compounds for cancer therapeutics. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4204-6.
- J Anguiano et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9(6):374-82.
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