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SP 600125
- NSC 75890
- Soluble in DMSO
- MF: C14H8N2O
- MW: 220.23
Description
Reversible ATP-competitive JNK inhibitor (IC50 values 40 nM, 40 nM, and 90 nM for JNK1, JNK2 and JNK3, respectively) with >20-fold selectivity vs. a range of kinases and enzymes tested. SP600125 caused G2/M cell cycle arrest and elevation of cyclin B1 and p27(kip), thereby inhibiting cell proliferation and increasing apoptosis in multiple cell lines. Moreover, SP600125 dose dependently inhibits phosphorylation of c-Jun, the expression of inflammatory genes COX-2, IL-2, IFN-γ, TNF-α, and prevents activation and differentiation of primary human CD4 cell cultures; SP600125 has proven to be a useful tool for isolation, generation, derivatization and stabilization of naive human pluripotent stem cells in so called NHSM conditions developed at the Weizmann Institute of Science.
*Promotion: SP 600125 is also part of Inhibitor Set(s):
| Naive Stem Cell NHSM inhibitor Set (Axon 5010) |
More Information
| Parent CAS No. | 129-56-6 |
|---|---|
| Chemical Name | 2H-Dibenzo[cd,g]indazol-6-one |
| SMILES | N1=C2C3=C(C=CC=C3)C(=O)C3=C2C(=CC=C3)N1 |
| MFCD | MFCD00022289 |
| InChi | InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) |
| InChiKey | ACPOUJIDANTYHO-UHFFFAOYSA-N |
| CID | 8515 |
| Short Description | JNK inhibitor |
References
- B.L. Bennett et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13681-6.
- H.H. Xia et al. Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers. Cancer Lett. 2006 Sep 28;241(2):268-74.
- O. Gafni et al. Derivation of novel human ground state naive pluripotent stem cells. Nature 2013, 504, 282-286.
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