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GSK J4
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C24H27N5O2
- MW: 417.5
Description
Histone demethylase JMJD3/UTX inhibitor; blocks demethylation of histone H3K27; As a cell permeable ethyl ester derivative of GSK J1 (Axon 1934), it is a suitable prodrug form for cell-based studies. It is rapidly hydrolyzed in cells, generateing pharmacologically relevant intracellular concentrations of GSK-J1
More Information
| Parent CAS No. | 1373423-53-0 |
|---|---|
| Chemical Name | ethyl 3-(6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoate |
| SMILES | C(OCC)(=O)CCNC1C=C(N2CCC3=CC=CC=C3CC2)N=C(C2=NC=CC=C2)N=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28) |
| InChiKey | WBKCKEHGXNWYMO-UHFFFAOYSA-N |
| CID | 71729975 |
| Short Description | JMJD3/UTX inhibitor |
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