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JMJD6 inhibitor WL12
- Soluble in DMSO
- MF: C16H11N3O2
- MW: 277.28
Description
JMJD6 inhibitor WL12 is a first-in-class JMJD6 inhibitor with an IC50 value of 0.22 μM. The compound inhibits JMJD6-dependent cellular functions and suppresses proliferation of multiple cancer cell types, providing a valuable tool for investigating JMJD6 biology.
Jumonji domain-containing protein 6 (JMJD6) is an Fe(II)- and 2-oxoglutarate-dependent oxygenase implicated in epigenetic regulation, transcriptional control, RNA splicing, and cancer progression. Elevated JMJD6 expression has been associated with poor prognosis in several malignancies. JMJD6 inhibitor WL12 suppresses JMJD6-dependent proliferation of cervical and liver cancer cells, with IC50 values of 2.44 μM and 10.18 μM in HeLa and SMMC7721 cells, respectively. The compound serves as an important chemical probe for studying JMJD6 function in epigenetics, oncology, and transcriptional regulation.
Key Features
- First-in-class JMJD6 inhibitor
- IC50: 0.22 μM for JMJD6 inhibition
- Suppresses JMJD6-dependent cancer cell proliferation
- Active in cervical and liver cancer cell models
- Useful tool for epigenetics and cancer research
Applications
- JMJD6 biology and target validation studies
- Epigenetics and transcriptional regulation research
- Cancer biology and oncology investigations
- RNA splicing and gene expression studies
- Cervical and liver cancer research
More Information
| Parent CAS No. | 899548-78-8 |
|---|---|
| Chemical Name | 3-(1H-Imidazo[4,5-c]pyridin-2-yl)-6-methyl-2H-chromen-2-one |
| SMILES | C12N=C(C3=CC4C=C(C)C=CC=4OC3=O)NC1=CC=NC=2 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H11N3O2/c1-9-2-3-14-10(6-9)7-11(16(20)21-14)15-18-12-4-5-17-8-13(12)19-15/h2-8H,1H3,(H,18,19) |
| InChiKey | AFTXOIIKGOXDOT-UHFFFAOYSA-N |
| CID | 22424483 |
| Short Description | JMJD6 inhibitor |
