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GDC 0449

 - Vismodegib  - HhAntag 691
Axon 1500
CAS:  879085-55-9
Purity:  99%
  • Soluble in DMSO
  • MF:  C19H14Cl2N2O3S
  • MW:  421.3

Description

The first-in-class inhibitor of Hedgehog (Hh) signaling pathway; more specifically, an orally bioavailable and potent inhibitor of smoothened homologue (SMO); an investigational anti-cancer drug for Medulloblastoma, advanced basal cell skin cancer etc

More Information

Parent CAS No. 879085-55-9
Chemical Name 2-Chloro-N-(4-chloro-3-pyridin-2-yl-phenyl)-4-methanesulfonyl-benzamide
SMILES C1(C2C=CC=CN=2)C=C(NC(=O)C2C=CC(S(=O)(=O)C)=CC=2Cl)C=CC=1Cl
MFCD MFCD12407408
InChi InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
InChiKey BPQMGSKTAYIVFO-UHFFFAOYSA-N
CID 24776445
Short Description Hedgehog inhibitor

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