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Apilimod
- STA 5326
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C23H26N6O2
- MW: 418.49
Description
Potent and orally active inhibitor of the cytokines interleukin-12 (IL-12), and interleukin-23 (IL-23) production; potential regulators of certain autoimmune and inflammatory diseases. It is also found to be a potent and selective PIKfyve inhibitor.
The water-soluble dimesylate salt, Apilimod dimesylate, is available as well (Axon 2500).
Note: Apilimod (Axon 1369) or Apilimod dimesylate (Axon 2500) from Axon Medchem are fully QC-ed drug reference standards with approved bioactivities. Several prominent research laboratories have tested our samples with satisfactory testing results, evidenced by recent publications. There used to be the wrong isomer of Apilimod and its mesylate salt appeared on the reagent market from some other sources, which would be inactive in your assays. Be right about your drug!
More Information
| Parent CAS No. | 541550-19-0 |
|---|---|
| Chemical Name | N-[6-Morpholin-4-yl-2-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-yl]-N'-[1-m-tolyl-meth-(E)-ylidene]-hydrazine |
| SMILES | C1(OCCC2N=CC=CC=2)N=C(N/N=C/C2C=CC=C(C)C=2)C=C(N2CCOCC2)N=1 |
| MFCD | MFCD09954108 |
| InChi | InChI=1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+ |
| InChiKey | HSKAZIJJKRAJAV-KOEQRZSOSA-N |
| CID | 10173277 |
| Short Description | IL-12/23 and PIKfyve inhibitor |
References
- Wada et al: Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor. Blood, 2007, 109(3), 1156-1164.
- Wada et al: IL-12/IL-23 inhibitors: a promising approach to the treatment of inflammatory disorders. Drugs Fut. 2008, 33(1), 49-63.
- Gayle et al: Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma. Blood, 2017, 129(13), 1768–1778
- List of publications using Apilimod (Axon 1369) and Apilimod (Axon 2500) purchased from Axon Medchem
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