List of publications using Apilimod (Axon 1369) and Apilimod dimesylate (Axon 2500) purchased from Axon Medchem
(Total of 20 publication citations up to 2019)
2019
Hulseberg, C. E., Fénéant, L., Szymańska-de Wijs, K. M., Kessler, N. P., Nelson, E. A., Shoemaker, C. J., ... & White, J. M. Arbidol and other low-molecular-weight drugs that inhibit Lassa and Ebola viruses. Journal of virology, 2019, 93(8).
https://jvi.asm.org/content/93/8/e02185-18.full
Min, S. H., Suzuki, A., Weaver, L., Guzman, J., Chung, Y., Jin, H., ... & Seeholzer, S. H. PIKfyve deficiency in myeloid cells impairs lysosomal homeostasis in macrophages and promotes systemic inflammation in mice. Molecular and cellular biology, 2019. 39(21), e00158-19.
https://mcb.asm.org/content/39/21/e00158-19.full
Isobe, Y., Nigorikawa, K., Tsurumi, G., Takemasu, S., Takasuga, S., Kofuji, S., & Hazeki, K. PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel. The Journal of Biochemistry, 2019, 165(1), 75-84.
https://academic.oup.com/jb/article-abstract/165/1/75/5122774
Shi, Y., Lin, S., Staats, K. A., Li, Y., Chang, W. H., Hung, S. T., ... & Wen, X. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nature medicine, 2018, 24(3), 313.
https://www.nature.com/articles/nm.4490.pdf?origin=ppub
https://jvi.asm.org/content/93/8/e02185-18.full
Min, S. H., Suzuki, A., Weaver, L., Guzman, J., Chung, Y., Jin, H., ... & Seeholzer, S. H. PIKfyve deficiency in myeloid cells impairs lysosomal homeostasis in macrophages and promotes systemic inflammation in mice. Molecular and cellular biology, 2019. 39(21), e00158-19.
https://mcb.asm.org/content/39/21/e00158-19.full
Isobe, Y., Nigorikawa, K., Tsurumi, G., Takemasu, S., Takasuga, S., Kofuji, S., & Hazeki, K. PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel. The Journal of Biochemistry, 2019, 165(1), 75-84.
https://academic.oup.com/jb/article-abstract/165/1/75/5122774
Shi, Y., Lin, S., Staats, K. A., Li, Y., Chang, W. H., Hung, S. T., ... & Wen, X. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nature medicine, 2018, 24(3), 313.
https://www.nature.com/articles/nm.4490.pdf?origin=ppub
2018
Wallner, F. K., Hopkins, M. H., Woodworth, N., Bark, T. L., Olofsson, P., & Tilevik, A. Correlation and cluster analysis of immunomodulatory drugs based on cytokine profiles. Pharmacological Research, 2018, 128, 244-251.
https://www.sciencedirect.com/science/article/pii/S1043661817311611
https://www.sciencedirect.com/science/article/pii/S1043661817311611
*Apilimod dimesylate purchased from Axon Medchem
Sbrissa, D., Naisan, G., Ikonomov, O. C., & Shisheva, A. Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns (3, 5) P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation. PloS one, 2018, 13(9), e0204532.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204532
Ikonomov, O. C., Altankov, G., Sbrissa, D., & Shisheva, A. PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation. Toxicology and applied pharmacology, 2018, 356, 151-158.
https://www.sciencedirect.com/science/article/pii/S0041008X18303582
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204532
Ikonomov, O. C., Altankov, G., Sbrissa, D., & Shisheva, A. PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation. Toxicology and applied pharmacology, 2018, 356, 151-158.
https://www.sciencedirect.com/science/article/pii/S0041008X18303582
2017
Gao, Q. (2017). Regulation of Lysosomal Adaptation to Nutrient Starvation by Lysosomal TRPML1 and PIKfyve (Doctoral dissertation).
https://deepblue.lib.umich.edu/handle/2027.42/138614
Tilevik, A. (2017). Evaluation of clustering methods for analyzing drug cytokine profiles.
https://www.diva-portal.org/smash/record.jsf?pid=diva2:1145108
*Apilimod dimesylate used in this study was obtained from Axon Medchem
Tronchere, H., Cinato, M., Timotin, A., Guitou, L., Villedieu, C., Thibault, H., ... & Kunduzova, O. Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice. EMBO molecular medicine, 2017, 9(6), 770-785.
https://www.embopress.org/doi/full/10.15252/emmm.201607096
Wallner, F. K., Hopkins, M. H., Lindvall, T., Olofsson, P., & Tilevik, A. Cytokine correlation analysis based on drug perturbation. Cytokine, 2017, 90, 73-79.
https://www.sciencedirect.com/science/article/pii/S1043466616305555
Nelson, E. A., Dyall, J., Hoenen, T., Barnes, A. B., Zhou, H., Liang, J. Y., ... & Morris, P. J. The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection. PLoS neglected tropical diseases, 2017, 11(4), e0005540.
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005540&rev=1
Morris, P. J., Moore, C., & Thomas, C. J. Apilimod. IUCrData, 2017, 2(5), x170693.
https://scripts.iucr.org/cgi-bin/paper?zl4016
Sahoo, N., Gu, M., Zhang, X., Raval, N., Yang, J., Bekier, M., ... & Samie, M. Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle. Developmental cell, 2017, 41(3), 262-273.
https://www.sciencedirect.com/science/article/pii/S1534580717302964
Mironova, Y. A., Lenk, G. M., Lin, J. P., Lee, S. J., Twiss, J. L., Vaccari, I., ... & Shrager, P. (2016). PI (3, 5) P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms. Elife, 2017, 5, e13023.
https://elifesciences.org/articles/13023
Gao, Q. (2017). Regulation of Lysosomal Adaptation to Nutrient Starvation by Lysosomal TRPML1 and PIKfyve (Doctoral dissertation).
https://deepblue.lib.umich.edu/handle/2027.42/138614
Tilevik, A. (2017). Evaluation of clustering methods for analyzing drug cytokine profiles.
https://www.diva-portal.org/smash/record.jsf?pid=diva2:1145108
*Apilimod dimesylate used in this study was obtained from Axon Medchem
Tronchere, H., Cinato, M., Timotin, A., Guitou, L., Villedieu, C., Thibault, H., ... & Kunduzova, O. Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice. EMBO molecular medicine, 2017, 9(6), 770-785.
https://www.embopress.org/doi/full/10.15252/emmm.201607096
Wallner, F. K., Hopkins, M. H., Lindvall, T., Olofsson, P., & Tilevik, A. Cytokine correlation analysis based on drug perturbation. Cytokine, 2017, 90, 73-79.
https://www.sciencedirect.com/science/article/pii/S1043466616305555
Nelson, E. A., Dyall, J., Hoenen, T., Barnes, A. B., Zhou, H., Liang, J. Y., ... & Morris, P. J. The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection. PLoS neglected tropical diseases, 2017, 11(4), e0005540.
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005540&rev=1
Morris, P. J., Moore, C., & Thomas, C. J. Apilimod. IUCrData, 2017, 2(5), x170693.
https://scripts.iucr.org/cgi-bin/paper?zl4016
Sahoo, N., Gu, M., Zhang, X., Raval, N., Yang, J., Bekier, M., ... & Samie, M. Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle. Developmental cell, 2017, 41(3), 262-273.
https://www.sciencedirect.com/science/article/pii/S1534580717302964
Mironova, Y. A., Lenk, G. M., Lin, J. P., Lee, S. J., Twiss, J. L., Vaccari, I., ... & Shrager, P. (2016). PI (3, 5) P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms. Elife, 2017, 5, e13023.
https://elifesciences.org/articles/13023
2016
Krishna, S., Palm, W., Lee, Y., Yang, W., Bandyopadhyay, U., Xu, H., ... & Overholtzer, M. PIKfyve regulates vacuole maturation and nutrient recovery following engulfment. Developmental cell, 2016, 38(5), 536-547.
https://www.sciencedirect.com/science/article/pii/S1534580716305524
Krishna, S., Palm, W., Lee, Y., Yang, W., Bandyopadhyay, U., Xu, H., ... & Overholtzer, M. PIKfyve regulates vacuole maturation and nutrient recovery following engulfment. Developmental cell, 2016, 38(5), 536-547.
https://www.sciencedirect.com/science/article/pii/S1534580717302964
2015
Weaver, J. R., Nadler, J. L., & Taylor-Fishwick, D. A. Interleukin-12 (IL-12)/STAT4 axis is an important element for β-Cell dysfunction induced by inflammatory cytokines. PLoS One, 2015, 10(11), e0142735.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142735
Hong, N. H., Qi, A., & Weaver, A. M. PI (3, 5) P2 controls endosomal branched actin dynamics by regulating cortactin–actin interactions. Journal of Cell Biology, 2015, 210(5), 753-769.
https://rupress.org/jcb/article/210/5/753/38281/PI-3-5-P2-controls-endosomal-branched-actin
Krishna, S., Palm, W., Lee, Y., Yang, W., Bandyopadhyay, U., Xu, H., ... & Overholtzer, M. PIKfyve regulates vacuole maturation and nutrient recovery following engulfment. Developmental cell, 2016, 38(5), 536-547.
https://www.sciencedirect.com/science/article/pii/S1534580716305524
Krishna, S., Palm, W., Lee, Y., Yang, W., Bandyopadhyay, U., Xu, H., ... & Overholtzer, M. PIKfyve regulates vacuole maturation and nutrient recovery following engulfment. Developmental cell, 2016, 38(5), 536-547.
https://www.sciencedirect.com/science/article/pii/S1534580717302964
2015
Weaver, J. R., Nadler, J. L., & Taylor-Fishwick, D. A. Interleukin-12 (IL-12)/STAT4 axis is an important element for β-Cell dysfunction induced by inflammatory cytokines. PLoS One, 2015, 10(11), e0142735.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142735
Hong, N. H., Qi, A., & Weaver, A. M. PI (3, 5) P2 controls endosomal branched actin dynamics by regulating cortactin–actin interactions. Journal of Cell Biology, 2015, 210(5), 753-769.
https://rupress.org/jcb/article/210/5/753/38281/PI-3-5-P2-controls-endosomal-branched-actin
2013
Baird, A. M., Dockry, É., Daly, A., Stack, E., Doherty, D. G., O'Byrne, K. J., & Gray, S. G. IL-23R is epigenetically regulated and modulated by chemotherapy in non-small cell lung cancer. Frontiers in oncology, 2013, 3, 162.
https://www.frontiersin.org/articles/10.3389/fonc.2013.00162/full