Bulk Inquiry
(R)-(-)-Rolipram
- Optical Purity: >98% e.e.
- Soluble in DMSO and EtOH
- MF: C16H21NO3
- MW: 275.34
Description
(R)-(-)-Rolipram is the more pharmacologically active R-enantiomer of Rolipram and inhibits phosphodiesterase 4 (PDE4), increasing intracellular cAMP signaling.
Enantiomer-resolved rolipram studies help define stereoselective PDE4 inhibition and cAMP-dependent effects in immune, neuronal and glial systems. (R)-(-)-Rolipram is useful for CNS, inflammation and neuroprotection pathway research.
Key Features
- More active R-enantiomer of Rolipram
- Inhibits PDE4-mediated cAMP degradation
- Useful for stereoselective PDE4 pharmacology
- Relevant to inflammation and CNS signaling studies
Applications
- PDE4 inhibition assays
- cAMP pathway research
- Neuroinflammation and neuroprotection models
- Stereoselective pharmacology comparisons
Rolipram (Axon 1212) and (S)-(+)-Rolipram (Axon 1432) are also available for comparative studies.
More Information
| Parent CAS No. | 85416-75-7 |
|---|---|
| Chemical Name | (R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one |
| SMILES | C1(OC)C=CC([C@H]2CC(=O)NC2)=CC=1OC1CCCC1 |&1:6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1 |
| InChiKey | HJORMJIFDVBMOB-LBPRGKRZSA-N |
| CID | 448055 |
| Short Description | PDE4 inhibitor |
References
- HH Schneider et al. Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur J Pharmacol. 1986, 127(1-2), 105-15.
- DE Griswold et al. Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation. 1993, 17(3), 333–44.
- SJ Kanes et al. Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity. Neuroscience. 2006, 144, 239-46. PMID 17081698
- RW Chen et al. Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation. Neuroscience Letters. 2007, 418(2). 165–9.
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