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MDL 100907
- Volinanserin - (R)-(+)-MDL 100907
- Optical Purity: 98% e.e.
- Soluble in DMSO and EtOH
- MF: C22H28FNO3
- MW: 373.46
Description
More Information
| Parent CAS No. | 139290-65-6 |
|---|---|
| Chemical Name | (R)-(2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol |
| SMILES | C1(=CC=CC(OC)=C1OC)[C@H](O)C1CCN(CCC2C=CC(F)=CC=2)CC1 |&1:10,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1 |
| InChiKey | HXTGXYRHXAGCFP-OAQYLSRUSA-N |
| CID | 5311271 |
| Short Description | 5-HT2A antagonist |
References
- SM Sorensen et al. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. JPET 1993, 266(2), 684-691.
- J H Kehne et al. Effects of the Selective 5-HT2A Receptor Antagonist MDL 100,907 on MDMA-Induced Locomotor Stimulation in Rats.Neuropsychopharmacol. 1996, 15, 116-124.
- T de Paulis. M-100907 (Aventis). Curr Opin Investig Drugs. 2001, 2(1), 123-32.
- GB Vary et al. M100907, a serotonin 5-HT2A receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and Wistar rats. Neuropsychopharmacol. 1999, 20(4), 311-21.
- RY Wang and X Liang. M100907 and Clozapine, but not Haloperidol or Raclopride, Prevent Phencyclidine-Induced Blockade of NMDA Responses in Pyramidal Neurons of the Rat Medial Prefrontal Cortical Slice. Neuropsychopharmacol. 1998, 19, 74-85.
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