Small molecule upregulator of the Survival of Motor Neuron protein (SMN; EC50 value 18 μM in SMA patient fibroblast cells); a tool compound that revealed that increasing Ras signaling upregulates SMN protein levels by increased phosphorylation of Erk, an important member of the Ras-Raf-MEK signaling cascade.

KEYWORDS: Cuspin 1 | Supplier | SMN upregulator | Axon Medchem | Axon 2438 | Cuspin1 | CAS [337932-29-3] | GTP | RAS | RAF | MEK | ERK | Activator | Enzymes | Survival of Motor Neuron Protein | SMN | SMA | fibroblasts | Spliceosome | RNP