Spliceosome

The spliceosome is a large macromolecular ribonucleoprotein (RNP) complex responsible for catalyzing pre-mRNA splicing (removal of introns from exons) and is composed of five small nuclear ribonucleoproteins (snRNPs; U1-U2 and U4-U6) and as many as 300 distinct proteins. In turn, snRNPs are build up of a ring of seven Sm proteins and a set of specific proteins (U1A, U1C and U1-70K). The survival motor neuron (SMN) protein complex, which includes SMN seven Gemin proteins (Gemin2–Gemin8) and unrip (also known as STRAP), is thought to regulate the entire cytoplasmic phase of the snRNP cycle[1],[2]


[1] T.W. Nilsen et al. The spliceosome: the most complex macromolecular machine in the cell? Bioessays. 2003 Dec;25(12):1147-9.
[2] A.G. Matera et al. A day in the life of the spliceosome. Nat Rev Mol Cell Biol. 2014 Feb;15(2):108-21.

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2438 Cuspin-1 Upregulator of the Survival of Motor Neuron protein (SMN) by Ras signaling activation €95.00

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