Risdiplam - RG7916

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Axon 3093

CAS [1825352-65-5]

MF C22H23N7O
MW 401.46

Purity: 99%
Soluble in 0.1N HCl (aq)

Risdiplam

Description

Risdiplam is a selective survival of motor neuron-2 (SMN2) gene splicing modifier (EC1.5x value of 4 nM).

KEYWORDS: Risdiplam | supplier | SMN2 modifier | RG7916 | RO7034067 | RG 7916 | RG-7916 | RO 7034067 | RO-7034067 | CAS [1825352-65-5] | [2304625-36-1] | [2304625-37-2] | RNA | SMN | Modifier | Proteins | Spinal muscular atrophy | SMA | Spliceosome

H Ratni et al. Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 ( SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA). J Med Chem. 2018 Aug 9;61(15):6501-6517

Selective SMN2 gene splicing modifier

Chemical name

2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

Parent CAS No.

[1825352-65-5]

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