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Axon 2241
CAS [1174043-16-3]
MF C22H22FN3O3MW 395.43
PARP inhibitor (IC50 value 5 nM) with poor P-glycoprotein substrate qualities. Unlike treatment with Olaparib (AZD2281; Axon 1464), AZD2461 succesfully circumvents drug resistance of Pgp-proficient tumors, and inactivation of p53-binding protein 1 (53BP1) as a causal factor in PARPi resistance.
KEYWORDS: AZD2461 | supplier | PARP inhibitor | AZD-2461 | AZD 461 | CAS [1174043-16-3] | DNA-RNA | PARP1 | P-gp | AZD2281 | Olaparib | drug resistance | tumors | p53 | binding protein 1 | 53BP1 | PARPi | resistance
4-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one
[1174043-16-3]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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