Olaparib - AZD2281 | KU-0059436

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1464

CAS [763113-22-0]

MF C24H23FN4O3
MW 434.46

Purity: 99%
Soluble in DMSO

Olaparib

Description

Highly potent, oral and selective inhibitor of poly(ADP-ribose) polymerase (PARP); with IC50 = 5nM (PARP-1) and 1 nM (PARP-2). It blocks enzymes that repair DNA damage caused by cancer treatments such as radiation and drugs.

KEYWORDS: Olaparib | PARP inhibitor | AZD2281 | KU-0059436 | AZD-2281 | AZD 2281 | KU 0059436 | KU0059436 | CAS [763113-22-0] | Axon Medchem | Axon 1464 | DNA-RNA | PARP | Inhibitor | Enzymes | poly-(ADP-ribose) polymerase | PARP-1 | PARP-2 | DNA damage | double strand break | DSB | CHK

KA Menear et al. 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J. Med. Chem. 2008, 51(20), 6581–6591.

S Rottenberg et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc. Nat. Acad. Sci. USA, 2008, 105(44), 17079–84.

T Hay et al. Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. Cancer Res. 2009, 69(9), 3850.

C Mitchell et al. Poly(ADP-Ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Carcinoma Cells. Mol. Pharmacol. 2010, 78(5), 909-917.

List of publications using AZD2281 (Axon 1464) purchased from Axon Medchem

PARP inhibitor

Chemical name

4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one

Parent CAS No.

[763113-22-0]

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5 mg	€50.00	In Stock
25 mg	€100.00	In Stock

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Olaparib - AZD2281 | KU-0059436

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