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Axon 3710
CAS [481629-87-2]
MF C28H27NO3MW 425.52
PAZ-417 is a potent, orally active and CNS-penetrant inhibitor of PAI-1 (IC50 value of 655 nM) that promotes plasmin formation and proteolysis of Aβ. In transgenic mouse models of Alzheimer’s disease, PAZ-417 reduces Aβ levels in both plasma and brain and reverses both LTP and cognitive deficits.
KEYWORDS: PAZ-417 | Supplier | PAI-1 inhibitor | Aleplasinin | PAZ417 | PAZ 417 | CAS [481629-87-2] | Serpin | Plasminogen activator inhibitor-1 (PAI-1) | Inhibitor | Enzymes | β-amyloid | Alzheimer's disease
2-(1-(4-tert-Butylbenzyl)-5-m-tolyl-1H-indol-3-yl)-2-oxoacetic acid
[481629-87-2]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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