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VU6036720 hydrochloride
- Optical Purity: 98.4% e.e.
- Soluble in DMSO and EtOH
- MF: C20H22ClFN4O2S.HCl
- MW: 473.39
Description
VU6036720 hydrochloride is the first potent and selective in vitro inhibitor of heteromeric Kir4.1/5.1 (KCNJ10/KCNJ16) inward rectifier potassium channels with and IC50 value of 0.24 μM.
The inactive (R)-enantiomer (Axon 3799) is also available.
More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | (S)-3-Chloro-N-(2-(4-(2-cyanophenyl)-2-methylpiperazin-1-yl)ethyl)-4-fluorobenzenesulfonamide hydrochloride |
| SMILES | C1N(C2C(C#N)=CC=CC=2)CCN(CCNS(=O)(=O)C2C=CC(F)=C(Cl)C=2)[C@H]1C.Cl |&1:27,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C20H22ClFN4O2S.ClH/c1-15-14-26(20-5-3-2-4-16(20)13-23)11-10-25(15)9-8-24-29(27,28)17-6-7-19(22)18(21)12-17;/h2-7,12,15,24H,8-11,14H2,1H3;1H/t15-;/m0./s1 |
| InChiKey | ZRUTWJFQZLMEBJ-RSAXXLAASA-N |
| CID | 167530052 |
| Short Description | Kir4.1/5.1 inhibitor |
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