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Loviride
- R 89439
- Soluble in DMSO
- MF: C17H16Cl2N2O2
- MW: 351.23
Description
Loviride is a potent and highly selective HIV-1 reverse transcriptase inhibitor with an IC50 value of 0.3 μM.
More Information
| Parent CAS No. | 147362-57-0 |
|---|---|
| Chemical Name | 2-((2-Acetyl-5-methylphenyl)amino)-2-(2,6-dichlorophenyl)acetamide |
| SMILES | C1C(Cl)=C(C(C(N)=O)NC2C=C(C)C=CC=2C(=O)C)C(Cl)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H16Cl2N2O2/c1-9-6-7-11(10(2)22)14(8-9)21-16(17(20)23)15-12(18)4-3-5-13(15)19/h3-8,16,21H,1-2H3,(H2,20,23) |
| InChiKey | CJPLEFFCVDQQFZ-UHFFFAOYSA-N |
| CID | 3963 |
| Short Description | NNRT inhibitor |
References
- R Pauwels et al. Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase. Proc Natl Acad Sci USA 1993 Mar 1;90(5):1711-5.
- M Witvrouw et al. Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV. AIDS. 1999 Aug 20;13(12):1477-83.
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