LY2857785

Based on 3 reference(s) in Google Scholar 8 10 3

Axon 3283

CAS [1619903-54-6]

MF C26H36N6O
MW 448.60

  • Purity: 98%
  • Soluble in 0.1N HCl(aq) and DMSO
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LY2857785

Description

LY2857785 is a highly potent and selective type I reversible and competitive ATP kinase CDK9 inhibitor with an IC50 value of 0.011 μM. LY2857785 significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines.

KEYWORDS: LY2857785 | supplier | CDK9 inhibitor | LY 2857785 | LY-2857785 | CAS [1619903-54-6] | [1619903-55-7] | DNA-RNA | CDK9 | Inhibitor | Enzymes | Circadian clock | REV-ERBα

Highly potent, selective, reversible and ATP-competitive CDK9 inhibitor

Chemical name

trans-N1-(4-(3-Isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-N4-(tetrahydro-2H-pyran-4-yl)cyclohexane-1,4-diamine

Parent CAS No.

[1619903-54-6]

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Size Unit Price Stock
5 mg €180.00 In Stock
25 mg €640.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €280.00 In Stock
2 x 25 mg €960.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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