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PSB-KD107
- Soluble in DMSO
- MF: C20H22N6O2
- MW: 378.43
Description
PSB-KD107 is a selective, non-lipid-like agonist for GPR18 with an EC50 value of 0.562 μM for human GPR18. Moreover, PSB-KD107 was more potent and much more efficacious than the standard GPR18 agonist THC. PSB-KD107 had also been identified as a moderately potent antagonist for the human adenosine A2A receptor with a Ki value of 4.56 μM.
More Information
| Parent CAS No. | 955121-65-0 |
|---|---|
| Chemical Name | 9-(2-(1H-Indol-3-yl)ethyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimido[1,2-f]purine-2,4(1H,3H)-dione |
| SMILES | N1(C)C(=O)C2N3CCCN(CCC4C5C=CC=CC=5NC=4)C3=NC=2N(C)C1=O |
| MFCD | N.A. |
| InChi | InChI=1S/C20H22N6O2/c1-23-17-16(18(27)24(2)20(23)28)26-10-5-9-25(19(26)22-17)11-8-13-12-21-15-7-4-3-6-14(13)15/h3-4,6-7,12,21H,5,8-11H2,1-2H3 |
| InChiKey | PUJKERUFRDZALE-UHFFFAOYSA-N |
| CID | 44437220 |
| Short Description | GPR18 agonist |
References
- A Drabczyńska et al. Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: structure-activity relationships as adenosine A(1) and A(2A) receptor ligands. Bioorg Med Chem. 2007 Nov 15;15(22):6956-74.
- CT Schoeder et al. Discovery of Tricyclic Xanthines as Agonists of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18. ACS Med Chem Lett. 2020 Jun 17;11(10):2024-2031.
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