Dacomitinib - PF-00299804

Based on 233 reference(s) in Google Scholar 8 10 233

Axon 3235

CAS [1110813-31-4]

MF C24H25ClFN5O2
MW 469.94

  • Purity: 100%
  • Soluble in 0.1N HCl(aq) and DMSO
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Dacomitinib

Description

Dacomitinib is a potent irreversible pan-ERBB inhibitor with IC50 values of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively. Dacomitinib is a potent inhibitor of EGFR-activating mutations as well as the EGFR T790M resistance mutation both in vitro and in vivo. Additionally, Dacomitinib is a highly effective inhibitor of both the wild-type ERBB2 and the gefitinib-resistant oncogenic ERBB2 mutation identified in lung cancers.
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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