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Axon 3232
CAS [1847461-43-1]
MF C32H39N7O4MW 585.70
TAK-788 is a potent and selective dual EGFR/HER2 tyrosine kinase inhibitor. Specifically, TAK-788 inhibited all 14 mutant variants of EGFR (IC50 values between 2.4 and 22 nM), and all 6 mutant variants of HER2 (IC50 values between 2.4 and 26 nM), more potently than it inhibited WT EGFR (IC50 value of 35 nM), including all 8 variants with exon 20 activating insertions.
KEYWORDS: TAK-788 | supplier | EGFR/HER2 inhibitor | Mobocertinib | AP32788 | TAK 788 | TAK788 | AP 32788 | AP-32788 | CAS [1847461-43-1] | Non Selective (Phosphorylation Substrates) | EGFR | ErbB2-HER2 | Inhibitor | Receptors | Non-small cell lung cancer | NSCLC
Isopropyl 2-(5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenylamino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate
[1847461-43-1]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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