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EMI48
- Soluble in DMSO
- MF: C21H20N2O3
- MW: 348.4
Description
EMI48 is an inhibitor of EGFR triple mutants. Moreover, EMI48 strongly inhibited total EGFR levels, activation and downstream signaling with effects observed at a 5 µM concentration. EMI48 did not affect interphase microtubules, or have an effect on spindle formation in PC9 EGFR ex19del/T790M/C797S cells.
More Information
| Parent CAS No. | 34564-13-1 |
|---|---|
| Chemical Name | 7-(Diethylamino)-3-(5-methylbenzo[d]oxazol-2-yl)-2H-chromen-2-one |
| SMILES | C1C=C2C=C(C3=NC4C=C(C)C=CC=4O3)C(=O)OC2=CC=1N(CC)CC |
| MFCD | N.A. |
| InChi | InChI=1S/C21H20N2O3/c1-4-23(5-2)15-8-7-14-11-16(21(24)26-19(14)12-15)20-22-17-10-13(3)6-9-18(17)25-20/h6-12H,4-5H2,1-3H3 |
| InChiKey | PTAGJQADNFQMGR-UHFFFAOYSA-N |
| CID | 15538560 |
| Short Description | EGFR inhibitor |
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