Islatravir - EFdA | MK-8591

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3191

CAS [865363-93-5]

MF C12H12FN5O3
MW 293.25

Purity: 99%
Optical purity: Optically pure
Soluble in water and DMSO

Islatravir

Description

The nucleoside reverse transcriptase inhibitor (NRTI) Islatravir is a potent and long-acting anti-human immunodeficiency virus type 1 (HIV-1) agent. Islatravir exhibits potent activity against wild-type and multidrug-resistant HIV-1 strains.

KEYWORDS: Islatravir | supplier | NRT inhibitor | EFdA | MK-8591 | MK 8591 | MK8591 | CAS [865363-93-5] | DNA-RNA | RT | Inhibitor | Enzymes

H Nakata et al. Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. Antimicrob Agents Chemother. 2007 Aug;51(8):2701-8.

KA Kirby et al. The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase. Cell Mol Biol (Noisy-le-grand). 2011 Feb 12;57(1):40-6.

Y Takamatsu et al. The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase. Cell Chem Biol. 2018;25(10):1268‐1278.e3.

Immunology RT EC 2.7.7.49

Potent and long-acting NRT inhibitor (HIV-1)

Chemical name

(2R,3S,5R)-5-(6-Amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol

Parent CAS No.

[865363-93-5]

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Size	Unit Price	Stock
2 mg	€140.00	In Stock
5 mg	€280.00	In Stock
25 mg	€1,060.00	In Stock

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2 x 5 mg	€480.00	In Stock

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Islatravir - EFdA | MK-8591

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Islatravir - EFdA | MK-8591

Description

Chemical name

Parent CAS No.

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