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Efavirenz
- DMP-266 - L-743,726
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C14H9ClF3NO2
- MW: 315.67
Description
Efavirenz is a highly potent, orally bioavailable nonnucleoside inhibitor of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Moreover, Efavirenz inhibited wild-type HIV-1 RT with a Ki value of 2.93 nM, and exhibited a 95% inhibitory concentration of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.
More Information
| Parent CAS No. | 154598-52-4 |
|---|---|
| Chemical Name | (S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one |
| SMILES | C1(Cl)C=C2[C@@](C#CC3CC3)(C(F)(F)F)OC(=O)NC2=CC=1 |&1:4,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 |
| InChiKey | XPOQHMRABVBWPR-ZDUSSCGKSA-N |
| CID | 64139 |
| Short Description | NNRT inhibitor |
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